Recent improvements to the PROSITE database

نویسندگان

  • Nicolas Hulo
  • Christian J. A. Sigrist
  • Virginie Le Saux
  • Petra S. Langendijk-Genevaux
  • Lorenza Bordoli
  • Alexandre Gattiker
  • Edouard De Castro
  • Philipp Bucher
  • Amos Bairoch
چکیده

The PROSITE database consists of a large collection of biologically meaningful signatures that are described as patterns or profiles. Each signature is linked to documentation that provides useful biological information on the protein family, domain or functional site identified by the signature. The PROSITE web page has been redesigned and several tools have been implemented to help the user discover new conserved regions in their own proteins and to visualize domain arrangements. We also introduced the facility to search PDB with a PROSITE entry or a user's pattern and visualize matched positions on 3D structures. The latest version of PROSITE (release 18.17 of November 30, 2003) contains 1676 entries. The database is accessible at http://www.expasy.org/prosite/.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

iProsite: an improved prosite database achieved by replacing ambiguous positions with more informative representations

PROSITE database contains a set of entries corresponding to protein families, which are used to identify the family of a protein from its sequence. Although patterns and profiles are developed to be very selective, each may have false positive or negative hits. Considering false positives as items that reduce the selectiveness of a pattern, then, the more selective pattern we have, a more accur...

متن کامل

The ProDom database of protein domain families

The ProDom database contains protein domain families generated from the SWISS-PROT database by automated sequence comparisons. It can be searched on the World Wide Web (http://protein.toulouse.inra. fr/prodom.html ) or by E-mail ([email protected]) to study domain arrangements within known families or new proteins. Strong emphasis has been put on the graphical user interface which allows ...

متن کامل

Protein Sequence Grouping by Peptide Word Motifs

Methods for collecting related segments from the protein sequence database using strongly conserved peptide words as well as sequence homology was applied to the problem of reconstruction of PROSITE catalog [1] from the sequence database. In many case our results were well consistent with PROSITE although some additional relationships were also found.

متن کامل

PROSITE: A Documented Database Using Patterns and Profiles as Motif Descriptors

Among the various databases dedicated to the identification of protein families and domains, PROSITE is the first one created and has continuously evolved since. PROSITE currently consists of a large collection of biologically meaningful motifs that are described as patterns or profiles, and linked to documentation briefly describing the protein family or domain they are designed to detect. The...

متن کامل

The PROSITE database, its status in 1995

The PROSITE database consists of biologically significant patterns and profiles formulated in such a way that with appropriate computational tools it can help to determine to which known family of proteins (if any) a new sequence belongs or which known domain(s) it contains.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Nucleic acids research

دوره 32 Database issue  شماره 

صفحات  -

تاریخ انتشار 2004